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doi: 10.1101/2023.01.09.523369 123 SakakibaraYYamashiroRChikamatsuSHirotaYTsubokawaYNishijimaRet al
As the terminal stage of various CVDs, HF is associated with a persistently high rate of morbidity, hospital readmission, and mortality in patients and has become a major public health problem worldwide, with more than 60 million cases diagnosed globally (90)
The combination of these three mechanisms makes Retatrutide unique among next-generation metabolic peptides
This activation subsequently triggered the PI3K/Akt/mTOR signaling pathway, ultimately preventing ischemic stroke-induced ferroptosis in endothelial cells (Hu et al., 2024)
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