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Other data used in this study will be made available to qualified researchers upon reasonable request for research purposes, and may be subject to a data use agreement

58,59,60,61 The endogenous inhibitors of MMPs are tissue inhibitors of metalloproteinases (TIMPs)

23 After 6 months of supplementation, 74% in the B12 group had reached no aphthous ulcer status, compared with 32% in the placebo group

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Results Vitamin B12 supplementation was associated with a significant increase in serum cobalamin levels across all routes of administration (pooled mean difference = +402.6 pg/mL