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Findings: RCTSTEP 3 Trial - Wegovy vs Placebo for Weight Loss in Overweight Adults Without DM, JAMA (2021) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=611 | length = 68 weeks) in overweight or obese adults (average weight 233 lbs | average BMI 38) without diabetes Treatment: Wegovy 2.4 mg sub-q once weekly vs Placebo

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The primary concern relates to delayed gastric emptying , which could potentially increase the risk of pulmonary aspiration during anaesthesia

Ozempic injection is a pre-filled pen injected under the skin (subcutaneously)

It explains both its ~14.9% peak weight loss in STEP 1 and its dose-limiting nausea profile, gastric-emptying delay is the same pathway that drives upper-GI side effects