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doi: Grossmann, M., Anawalt, B.D

after 0.33g of compound 1 was dissolved in 100mL of acetonitrile, the mixture was added dropwise to the mixture, and reacted at 0 to 5 for 3 hours, the pH of the resulting reaction solution was adjusted to 4.0 with hydrochloric acid, then 2-fold purified water was added, and centrifugation was carried out to obtain solid compound 2, and the liquid chromatogram in FIG

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Hyer, MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo