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Post-operative return to training, meet-timing options, supplement stacks, and the role of GLP-1 receptor agonists in chronic anti-inflammatory effects

Low-dose RES (20 M) downregulates GLUT1, decreasing glucose uptake, glycolysis, lactate production, and extracellular acidification, while enhancing glutamine metabolism through upregulation of ASCT2 and GLS2

Additionally, we find that the decrease in glutamate brought by acivicin could be rescued by administration of pyroglutamate (5-oxoproline), a downstream metabolite in the glutathione pathway that is a precursor of glutamate (Fig