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Rut also significantly inhibit the activation of MAPK signaling pathway induced by cerebral ischemia-reperfusion, reduce the expression of apoptosis related proteins and the occurrence of apoptosis, indicating that Rut can play an anti apoptotic role in reducing nerve injury by inhibiting MAPK signaling pathway (Zhang et al

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Offline analysis of the data obtained from electrophysiological recordings was conducted using Clampfit software version 10.7 (Axon Instruments, Inc., USA)