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Acknowledgements This work was supported by National Natural Science Foundation of China (Grant number: 30400077), University of Gdask (task grant no

By encouraging nutritional supplementation, limiting pathogen colonization, preserving normal mucosal immunity, and controlling fat storage and metabolism, the gut microbiotaalso known as the "second genome"play a critical role in human nutrition and health (Zhang et al., 2020)

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Their rules are intentionally written to be forward-looking, banning substances by their function, not just their name