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Mechanisms of fat loss: Increases lipolysis (breakdown of stored fat) Enhances metabolic rate Targets visceral fat (around organs) preferentially Improves fat oxidation for energy Preserves muscle while losing fat Body recomposition: Unlike stimulant-based fat burners, Ipamorelin works through hormonal optimization

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Moreover, weight cycling has previously been associated with lower muscle mass and strength, as well as an increased risk of SO [99, 100]

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021