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Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity

(A and B) Immunoblotting assays showing shCD36 reverses BRD4 and AR degradation by SIM1-Me (A) and ARV-110 (B), respectively, in LNCaP cells under indicated conditions.(E and F) Immunoblotting assays showing increasing expression of HA-tagged CD36 protein in shCD36-LNCaP cells restores BRD4 and AR degradation by SIM1-Me (E) and ARV-110 (F), respectively, in LNCaP cells under indicated conditions.(GJ) Viability of shEEA1+Vec-, shLuc+Vec-, shCD36+Vec-, shCD36+CD36-LNCaP cells determined by MTT assays after incubation with increasing concentrations of SIM1-Me (G), ARV-110 (H), MZ1 (I), or paclitaxel (J)

doi: 10.1007/s10815-012-9714-1 194 YoussefMAAbdelmotyHIElashmwiHAAbduljawadEMElghamaryNMagdyAet al

Arthritis Res Ther 2023

By cutting down on oxidative stress, it helps stave off those not-so-fun age-related ailments like forgetfulness, energy failures, and the big C (NCBI)