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8,17,132-137 Given that ME/CFS symptoms recur in some improved patients who discontinue therapies, suggesting suboptimal clearance of the underlying pathology, there is increasing speculation that combinations may be more efficacious than single treatments

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The study indicates that the process is due to the transdifferentiation between islet cells, and the intestine-islet GLP-1/GLP-1R/PKA signal pathway is one of the important pathways to produce this process ( GLP-1 is one of the hormones responsible for the incretin effect, and exerts a wide variety of actions such as potentiation of glucose-stimulated insulin secretion, reduction of appetite, delay of gastric emptying and inhibit cell dysfunction ( PC1/3 and PC2, as the important proteases of cell, play an important role in the process of transforming proinsulin into insulin ( In order to have a further study about the effect of berberine on GLP-1/GLP-1R/PKA signaling pathway, we performed experiment in vitro