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When you experience stress, your body puts energy toward creating stress hormones like cortisol rather than creating sex hormones like estrogen and testosterone

However, these results may be due to weight loss rather than to the GLP-1RA medication sepecifically

Meanwhile, obesity or overweight, worse renal function, unfavorable lipid profile (such as higher low-density lipoprotein cholesterol and lower high-density lipoprotein cholesterol), hypertension, and smoking are also associated with a higher risk of DPN ( 2.3 Pharmacological treatments for DPN According to the relevant guidelines in China released in 2021 ( 3 Preclinical evidence of neuroprotective effects of GLP-1R agonists in DPN In patients with DM, the metabolism of glucose, lipids, proteins, and nuclear acids is largely dysregulated

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Patients often report that sugar no longer provides the same emotional or physical reward it once did