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The independent variables of total AQ score and OCI-R obsessions subscales were mean-centred to reduce multicollinearity prior to the creation of the interaction terms [17, 45]

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According to the review, lower vitamin D levels before sleep may be associated with increased conversion of serotonin, another hormone, to melatonin

Synthesis of Results The primary meta-analysis pooled all RCTs across depression rating scales using standardized mean difference (SMD) random effects (REML)

Before any medication is started, patients go through a full metabolic workup, relevant lab testing, and a real planning conversation about goals, expectations, and potential obstacles