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FIGURE 3 7.1 Neurotoxicity and cognitive impairments Heroin-induced oxidative stress disrupts the balance between oxidation and antioxidation (Xu et al., 2006), leading to neuronal death and BBB disruption during withdrawal (Sharma and Ali, 2006)

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After a 3 h attachment period, the medium was replaced by 0.5 ml of fresh medium per well, containing the NAs of interest or the positive and negative controls

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