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PCT/IE 2008/000091

Additionally, GLP-1 signalling in the prefrontal cortex may hypothetically enhance cognitive control and decision-making processes, potentially helping individuals resist urges to drink, though this mechanism is primarily supported by animal models rather than human data

& Arciero, P

The localization of FUNDC1 at ER-mitochondria contact sites (MAMs) and its role in integrating mitophagy, mitochondrial adaptation, and ER stress responses exemplify how spatial organization determines functional proteostasis outcomes

While theyre not a cure for underlying GI disorders, clinical evidence and real-world use suggest they can provide meaningful relief in targeted situations