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For instance, a longitudinal study in stroke patients revealed that gut microbiota dysbiosis (e.g., reduced Roseburia levels) at admission independently predicted the risk of subsequent stroke-associated pneumonia (SAP)

Oxidative stress can influence drug protein-adduct formation by multiple mechanisms, including induction of conformational alterations or oxidative modifications that can either increase or blunt the reactivity of the modified residues towards the drug, as we have recently reviewed (Gonzlez-Morena et al., 2016)

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Animal LD50 studies showed toxic levels around 320 mg/kg body weight, translating to approximately 22,400 mg for a 70 kg human

RSL-3 blocks GPX4, which increases the levels of ROS and malondialdehyde (MDA) inside cells and promotes ferroptosis by blocking the SLC7A11/GSH/GPX4 pathway (73)