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Injectable forms are often considered more effective for systemic targets (tendons, joints, muscles) because they bypass digestive breakdown and provide higher bioavailability

In the 72-week SURMOUNT-5 trial described in this article, average weight reduction was 20.2% with tirzepatide and 13.7% with semaglutide among adults with obesity without type 2 diabetes

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Chassaing B, Koren O, Goodrich JK, Poole AC, Srinivasan S, Ley RE, Gewirtz AT