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These increased inflammatory factors and chemokines leads to further infiltration of immune cells into the respiratory tract, resulting in dysfunctions of fibroblasts, goblet cells, and epithelial cells, ultimately leading to emphysema, mucus accumulation, inflammation, and pulmonary fibrosis [52]

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[36] Despite the many bans, European countries still hold 18 of the top 20 spots [37] Rates of smoking have leveled off or declined in the developed world but continue to rise in developing countries

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