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In DIO mice, PL7737 achieved significant weight reductions after just one day of treatment when orally administered once-daily at 10 and 30 mg/kg (137)

One phase IIb clinical trial administered setmelanotide to obese participants with heterozygous MC4R deficiency and obese controls over 28 days, observing a placebo-adjusted weight loss of 2.6 kg and 4.0 kg respectively [98]