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In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)
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10.1139/APNM-2020-0034 [DOI] [PubMed] [Google Scholar] Chen J, Xiao L, Chen Y et al (2022a) Butylphthalide alleviates sleep deprivation-induced cognitive deficit by regulating Nrf2/HO-1 pathway
While available for research use in places like the U.S., peptides are not officially approved for human use by regulatory agencies such as the FDA
Antioxid Redox Signal 19 , 13051320, (2013)
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