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Notably, a large proportion of HIV reservoir viral isolates were resistant to aNAb neutralization, which correlated with longer duration on uninterrupted ART, suggesting that selection for aNAb-resistant isolates occurs as reservoir cells containing neutralization-sensitive isolates are eliminated

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Illustratively, such linkers include fragments of the following formulae: wherein n is an integer selected from 1 to about 3, and m is an integer selected from 1 to about 22