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Nevertheless, contemporary research has revealed that the administration of metformin can trigger ferroptosis by counteracting the generation of lipid ROS through autophagy inhibition ( Nuclear receptor coactivator 4 (NCOA4) is a discerning receptor that upholds iron homeostasis by binding to ferritin, conveying ferritin to lysosomes, and stimulating autophagic degradation

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The preovulatory follicle has a potent antioxidant defense, which is depleted by the intense peroxidation [15]

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