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The other conserved residues in micro-switches (ERY, PIF, and NPxxY) also undergo active-like conformational changes relative to the antagonist-bound receptor and transmit the peptidic agonism signaling to the cytoplasmic end to facilitate receptor-G protein coupling

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The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

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Ryan TA, Phillips EO, Collier CL, Jb Robinson A, Routledge D, Wood RE, Assar EA, Tumbarello DA (2020) Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles