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Aging Cell 19, e13258

It generally requires preparing the patient, applying local anesthesia, aspirating fluid from the joint or bursa, and then administering the appropriate medication, like corticosteroids

We may recommend more frequent IVs

Another rat study found that acute restraint stress can upregulate TLR4 gene expression in the frontal cortex by inducing gut microbiota translocation, while intervention with antibiotics or the TLR4 specific inhibitor TAK-242 effectively suppresses this process and reduces the accumulation of inflammatory and oxidative/nitrosative mediators (163)