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Mechanistic Research Perspective Oxidative stress pathway investigation Redox signaling and antioxidant defense research Detoxification and conjugation pathway analysis Mitochondrial function and metabolic signaling studies Cellular protection and stress response modeling Primary Research Applications Oxidative Stress & Redox Balance Research: Glutathione is widely used to model cellular responses to oxidative stress and investigate redox regulation mechanisms

10.1006/bbrc.2000.3269

As MPs and NPs interact with the cellular microenvironment, increased ROS settle on the surface of MPs and NPs, leading to oxidative stress in the cell, which induces localized inflammation in the gut if MPs and NPs are unable to cross the cellular membrane (55)

These effects are attributed to its action on the NO system, enabling vascular tone adjustment according to physiological conditions

doi: 10.1210/endo.141.6.7503 62 NishiY.HiejimaH.HosodaH.KaiyaH.MoriK.FukueY.et al