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Overexpression of ACSL4 exacerbated ischemic brain injury in mice by promoting lipid peroxidation, neuronal death, and neuroinflammation

The peptide has the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, incorporating a lactam bridge that enhances metabolic stability and receptor selectivity

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For example, neuropeptide Y (NPY) aggravates PMO in OVX rats by modulating GM diversity and composition, thereby affecting circulating microbial metabolites ( Firmicutes and Bacteroidetes play a crucial role in osteoclast differentiation