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Lancet 392(10148):637649 Wadden TA, Bailey TS, Billings LK, Davies M, Frias JP, Koroleva A et al (2021) Effect of subcutaneous semaglutide vs placebo as an adjunct to intensive behavioral therapy on body weight in adults with overweight or obesity: the STEP 3 randomized clinical trial

Methionine, inositol, and choline support hepatic fat metabolism and methylation pathways

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Research on MOTS-c in ovariectomized mice (a model for postmenopausal metabolic dysfunction) showed reduced fat accumulation in white adipose tissue, increased brown fat activation, and improved insulin sensitivity after just 5 weeks of treatment