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Expert Rev Clin Immunol 7(3):287294

Glutathione serves as the primary substrate for the glutathione peroxidase (GPx) enzyme family, which neutralizes hydrogen peroxide and lipid hydroperoxides

PMID: 68 MihalasBPRedgroveKAMcLaughlinEANixonB

Fontana RJ

Glutathione supplementation supports thyroid health by reducing the need for selenium and providing the thyroid cells with an oxidative stress regulation tool they natively use.* Glutathione helps to recycle glutathione peroxidase, removing the toxic products the enzyme captures.* This means the thyroid cells will not need to produce extra glutathione peroxidase to cope with oxidative stress.* Additionally, glutathione neutralizes ROS directly, independent of the antioxidant-enabling activity it performs for glutathione peroxidase.* Using a glutathione supplement can thus modify the threat model of thyroid issues from selenium insufficiency or excess oxidative stress.* Rather than an individual with compromised thyroid function worrying about both impaired hormone production and thyroid damage, they would only need to be mindful of maintaining a minimum viable level of oxidative stress to provide for essential functions (although it is highly unlikely to fully deprive thyroid cells of the baseline level of oxidative stress they need to produce hormones)