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Moreover, the stepwise administration of amylin and GLP-1R analogs was able to break the plateau normally observed with individual pharmacotherapies, even when combined from the beginning of treatment, thus supporting the hypothesis that a stepwise-introduction of a combinatorial pharmacological approach at treating obesity is more effective in achieving a sustained and long-lasting degree of weight loss

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There have been some reports of digestive discomfort when people take large doses of L-carnitine