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Cardiovascular safety was demonstrated in the ORIGIN (glargine)56 and DEVOTE (degludec) trials.57 Basal insulin analogs (glargine U100 and U300, detemir, degludec) have shown a lesser risk of hypoglycemia (particularly nocturnal hypoglycemia) than human NPH insulin.58 The cost of such treatment is higher, and insulin degludec is the most expensive, its prescription within the public healthcare system currently being limited to authorized cases only

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doi:10.1007/s00266-008-9188-9 El Kamshoushy A, Abel Maksoud R, El Mahdy N

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