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GLP-1s Direct Biological Impact in the Brain Beyond their systemic metabolic effects, GLP-1 medications exert direct biological actions in the brain through widespread expression of incretin (GLP-1) receptors in regions critical for cognition, including the hippocampus, prefrontal cortex, and hypothalamus [14]

The whole process of radical-induced toxicity appears to stem from the generation of oxygen radicals (superoxide anion or singlet oxygen radical) from which other reactive oxygen species (ROS) and reactive nitrogen species (RNS) can be derived

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12 Respecto a la suplementacin con L-carnitina, se aplic Cardispan I.V., que es L-carnitina 50 mg/ kg/sesin y se prepar en un mililitro de solucin salina, en una jeringa de 20 mL, 30 minutos antes de terminar cada sesin de hemodilisis y se aplic sobre la lnea venosa.11 El cardispan fue proporcionado por la Unidad Mdica de Alta Especialidad, UMAE Hospital Gineco/pediatra 48 (UMAE 48) y fue aplicado por las enfermeras del rea de hemodilisis peditrica