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PTMs of key proteins such as ACSL4, SCD1, and ALOX15 (e.g., phosphorylation, SUMOylation) play crucial roles in tumor progression, chemoresistance, and tissue damage

To assess a contribution of de novo lipogenesis to this transient hepatic lipid overload, Srebf1 and Fasn mRNA levels were analyzed and both were elevated at 6 h post-G49 treatment (Fig

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Once these high-risk groups are clearly definedfor example, individuals with reduced mobility or sarcopenic obesityclinical management will likely first focus on optimizing lifestyle measures such as resistance training and adequate protein intake, before introducing additional pharmacological interventions such as emerging muscle-sparing drugs