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In this multicenter study conducted across 22 countries, participants (67.6% females and 72% White) received once-weekly subcutaneous administration of CagriSema ( n = 2,108) with dose escalation from 0.25 mg to a maximum of 2.4 mg for each drug, in addition to lifestyle intervention, compared with placebo ( n = 705)

Corrales FJ, Perez-Mato I, Sanchez del Pino MM, Ruiz F, Castro C, Garcia-Trevijano ER, Latasa U, Martinez-Chantar ML, Martinez-Cruz A, Avila MA, Mato JM: Regulation of mammalian liver methionine adenosyltransferase

There is some evidence that the diabetes drug metformin (Glucophage) may reduce vitamin B12 absorption when used for several years

5, 10.1038/srep09018 (2015)

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