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In a double-blind, placebo-controlled crossover protocol, two arms included eight athletes who took a placebo or zinc-carnosine, for 14 days

10.18632/aging.101759 145 ZhangY.ZhaoY.DongD.LiX.LiZ.LiS.et al (2020)

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Coya said the trial met its primary endpoint for safety and secondary endpoint for regulatory T cell (Treg) cell population enhancement, with no off-target effects on T effector lymphocytes, providing further evidence of target engagement in 22 patients dosed with five days of LD IL-2 (106 IU/day) or placebo every four weeks for 21 weeks

The SURMOUNT-4 trial presents another opportunity for tirzepatide to differentiate from Novos semaglutide