Possible Semaglutide Side Effects During the First Week As with all medications, the first week on semaglutide may be accompanied by side effects due to your body trying to adjust to it
To minimize these reactions, rotate injection sites each time you administer the medication for example, alternate between different areas on the abdomen or thigh
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Common side effects include nausea, vomiting, diarrhoea, constipation, abdominal discomfort, bloating, headache and fatigue
Separately, a large study published in Nature Communications in 2024 found that semaglutide was associated with a 50 to 56% reduction in the incidence and recurrence of alcohol use disorder compared to other weight management medications