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Cardiovascular Safety : The cardiovascular safety of tirzepatide has been evaluated and confirmed to date through a pre-specified meta-analysis of phase 2 and 3 randomized trials comparing tirzepatide with other placebo, insulin glargine, degludec, semaglutide, dulaglutide for a minimum of 26 weeks (including the GPGB, SURPASS 1,2,3,4,5, and J-mono studies) [67]

reliable systemic absorption Intravenous infusion Used in controlled pharmacokinetic characterization studies Intraperitoneal injection Common in rodent research protocols for systemic delivery Intranasal administration Investigated for GHRH analogs in sleep research applications Subcutaneous administration represents the most common research route due to ease of delivery, reproducible absorption kinetics, and sustained peptide exposure suitable for growth hormone secretion studies