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The BK channel opener BMS-191011 was shown to suppress behavioral evidence of salicylate-induced tinnitus in mice, with local application in the inferior colliculus reversing salicylate-suppressed spontaneous activity, particularly in the frequency region corresponding to the tinnitus percept, highlighting a key site of action see in Figure 2 - (Scott et al., 2022)

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Overall, its considered safe to take Vitex, like what is found Balance Womens Hormone Support formula, while taking birth controland in fact, it can help benefit womens hormones during reproductive years and during perimenopause