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This may involve mtDNA biomarker-guided ART selection, where screening for pre-existing mtDNA haplogroups or mutational burdens identifies individuals at higher risk for specific ART toxicities, enabling proactive selection of less harmful regimen (e.g., avoiding certain NRTIs in susceptible individuals)

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One study reported that the greater cognitive deficits seen in males with early MS correlated with more extensive white matter damage, particularly in the thalamus, which is a critical relay center in the brain (10)