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Moreover, most of the existing preclinical studies have relied on male rodents, neglecting sex-specific variants in gut microbiota compositions and neuroinflammatory responses (Chakraborty et al., 2025)

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Another characteristic of PD is oxidative DNA damage, which triggers PARP activation, leading to the depletion of NAD + levels 40,279,282,283,284

In addition to the transferase function, GSTs have been shown to form protein:protein interactions with members of the mitogen activated protein (MAP) kinase pathway thereby serving a regulatory role in the balance between cell survival and apoptosis