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The hypothalamic-pituitary-gonadal (HPG) axis is crucial for semen production and maintenance of sexual function in men (167) and thus reduces the pulsatile secretion of the major regulators of spermatogenesis: FSH, LH, and testosterone, affecting semen parameters (168)

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Future in vivo studies and clinical trials are certainly warranted to determine whether incretin receptor multi-agonists may outperform single GLP-1R agonists as a novel therapeutic option for human neurodegenerative diseases

Navarro J, Obrador E, Pellicer JA, Aseni M, Via J, Estrela JM