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Accordingly, a clinical trial evaluating the effect of weekly caloric reduction achieved with either caloric restriction or intermittent fasting in 29 overweight/obese individuals with ADPKD was recently completed (Hopp et al., 2021

The SELECT trial showed that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in people with overweight or obesity and established cardiovascular disease

Diarrhea can cause dehydration, especially if it lasts for multiple days

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The authors also emphasize that NAD dynamics vary by tissue and that results from animal studies cannot be directly translated to humans