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Nature 477:211215 Johnson JO, Mandrioli J, Benatar M et al (2010) Exome sequencing reveals VCP mutations as a cause of familial ALS

Evidence-based guidelines for the treatment of postmenopausal osteoporosis: a consensus document of the Belgian Bone Club

This is the rationale behind topical and oral use for eczema, psoriasis, and dermatitis, though dedicated human trials for those conditions are not there yet