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Where GLP-1s Shineand Where Cost Can Bite GLP-1s (semaglutide/tirzepatide) often produce greater average weight loss than phentermine, but can require years to do so

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The EM structure of Tirzepatide bound to the complete GIPR and G-proteins (Figure 3, PDB ID 7rbt, Sun et al., 2022) shows some hydrophobic and some specific polar interactions between the peptidic drug and the GIP receptor molecule