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Using respiratory epithelium cell cultures obtained from the nasal septum of mice, they showed that the respiratory epithelium exposure to the particulate phase as well as the gas phase of cigarette smoke causes a significant reduction in the percentage of cilia development (Figure 1), as well as reduction in their size (Figure 2)

Shortly after, some of the first reports of lung cancer began surfacing, with nearly 1,000 cases reported by the 1920s