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Compared with that in normal tumor cells, the intracellular drug concentration in resistant cells is well below the effective range due to enhanced drug efflux, reduced drug influx and drug sequestration ( Figure 1 )

however, they might also increase the risk of infection due to inhibition of SAA synthesis, thus requiring strict monitoring of therapeutic windows (83, 86)

10.1128/CMR.00338-20 407 SouzaP

Evidence suggests that people using GLP-1 therapies often experience changes in appetite, taste perception and food preferences, including a reduced desire for sweet and fatty foods