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To further elucidate the therapeutic mechanisms underlying D-CuPs multivalent interactions, comprehensive proteomic analysis revealed two pivotal transcriptional regulators, the tumor suppressor protein p53 and histone deacetylase 7 (HDAC7) to be potential mechanistic targets

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In contrast, untreated HepG2 ATP7B-KO cells were further separated from copper-treated HepG2 ATP7B-KO cells

This brings nutrients to the growing egg