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The nausea results from GLP-1 receptor activation in both the gut (slowing gastric emptying) and the brainstem (activating the area postrema)

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By activating GLP-1 receptors, semaglutide helps reduce appetite, slow gastric emptying, and support steady blood sugar regulation

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A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis. New England Journal of Medicine , vol

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