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TLR4 can enhance the production of pro-inflammatory cytokines and chemokines, such as IL-6 and IL-17, by binding with exogenous ligands, like peptidoglycan, in FLS and peripheral blood mononuclear (PBMC) from RA patients, and trigger cartilage inflammation and degeneration (135)

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Figure 1 ALC reduced plasma TC and LDL-C levels in C57BL/6J mice fed a high-cholesterol diet Building upon the clinical observations, among the differential plasma metabolites of patients with hyperlipidemia, ALC was significantly downregulated and negatively correlated with plasma LDL-C

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