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Concentration of GSH in tumor cells is reported to be approximately 210 mmol/L, which is 1001000 times higher than the blood and extracellular fluid concentrations [34, 70]

In the SURMOUNT-1 trial, tirzepatide 15 mg produced a mean weight reduction of 22.5% over 72 weeks in adults without diabetes, highlighting the potential value of multi-receptor metabolic therapy

This once again highlights the idea that the curves of asymmetry of the funnel plot are not likely attributable to systematic publication bias and tend to be more indicative of actual variation in the studies