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1 Type 2 diabetes mellitus (T2DM) accounts for roughly 90% to 95% of all diagnosed cases of diabetes in the U.S

The improved health includes cardiometabolic health (like type 2 diabetes and reduced cardiovascular outcomes) along with physical function and quality of life, said Nadolsky

To minimize the risk and intensity of gastrointestinal side effects, it is recommended to start with a low dose of semaglutide and gradually increase the dosage

Subjects were excluded if they had clinically significant concomitant diseases or disorders, clinically significant abnormal values in clinical laboratory screening tests, any history of gastrointestinal surgery, had used any prescription or non-prescription drugs within 3 weeks prior to dosing of trial product (except hormone replacement therapy, contraceptives and occasional use of paracetamol in the food-effect trial), were smokers (dosing conditions trial) or were not able or willing to refrain from smoking while staying at the clinic (food-effect trial), or if they were pregnant or breastfeeding women (food-effect trial)

Only 3.3% of STEP UP participants stopped treatment because of side effects