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doi: 10.1038/ki.2010.418 213

Patients can experience generalized tonic-clonic seizures, in which they fall down, shake and become unresponsive

It's like a breakthrough in another way is that here you have an ability to triumph over such a frustrating target, just like we've seen with Alzheimer's, of course, which may actually intersect with Alzheimer's, with a graveyard of failed drugs